Ligand id: 7208

Name: lansoprazole

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View more information in the IUPHAR Pharmacology Education Project: lansoprazole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 87.08
Molecular weight 369.08
XLogP 2.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat and prevent stomach and duodenal ulcers, reflux esophagitis and other conditions of acid over-production.
Mechanism Of Action and Pharmacodynamic Effects
Lansoprazole irreversibly inhibits the gastric potassium-transporting ATPase, which is composed of two subunits, ATP4A and ATP4B. This proton pump is responsible for secreting H+ ions into the stomach, creating acidic pH.
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