mitoxantrone

Ligand id: 7242

Name: mitoxantrone

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: mitoxantrone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 8
Rotatable bonds 12
Topological polar surface area 163.18
Molecular weight 444.2
XLogP -2.17
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat prostate cancer, metastatic breast cancer, some leukemias and to relieve the symptoms of relapsing multiple sclerosis.
Mechanism Of Action and Pharmacodynamic Effects
Mitoxantrone causes cross-links and strand breaks in DNA, interferes with RNA, and inhibits topoisomerase II. The result of these effects is cell death. See the DrugBank link for further details.
External links