Ligand id: 7247

Name: nefazodone

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View more information in the IUPHAR Pharmacology Education Project: nefazodone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 10
Topological polar surface area 39.26
Molecular weight 469.22
XLogP 5.03
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat depression, including major depressive disorder. Use of this drug has been discontinued in some countries due to drug-induced liver damage.
Mechanism Of Action and Pharmacodynamic Effects
Nefazodone has the over all effect of increasing serotonin signalling (antagonising post-synaptic receptors and inhibiting reuptake via SLC6A4) and antagonises α1-adrenoceptors.
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