Ligand id: 7261

Name: paramethadione

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 46.61
Molecular weight 157.07
XLogP 0.35
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to control absence seizures. The US FDA has discontinued marketing authorisation for this drug.
Mechanism Of Action and Pharmacodynamic Effects
This drug's molecular mechanism of action (MMOA) may involve inhibition of voltage-dependent T-type calcium channels. CACNA1E, CACNA1H and CACNA1I alpha subunits are detailed in this database, in the Voltage-gated calcium channels section. See the DrugBank link for further details.