polythiazide

Ligand id: 7274

Name: polythiazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 151.63
Molecular weight 438.97
XLogP 1.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat oedema of varied aetiology and to treat hypertension. Use of this drug has been discontinued in the US, but may continue in other countries.
Mechanism Of Action and Pharmacodynamic Effects
Reduces water retention by inhibiting Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys by inhibiting the Na-Cl symporter (SLC12A3).