Ligand id: 7276

Name: prilocaine

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View more information in the IUPHAR Pharmacology Education Project: prilocaine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 44.62
Molecular weight 220.16
XLogP 3.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Prilocaine is a local anesthetic used commonly in dental practice, administered parenterally by injection to induce nerve block. This drug may also be used to induce spinal anaesthesia for short term surgical procedures.
Mechanism Of Action and Pharmacodynamic Effects
Prilocaine blocks sodium channels located on neuronal membranes and thereby inhibits action potential and nerve signal propagation. The genes and proteins SNC1A-SNC11A are listed in this database in the voltage-gated sodium channels section.
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