Ligand id: 7287

Name: pyrazinamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 69.86
Molecular weight 123.04
XLogP 0.04
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat tuberculosis.
Mechanism Of Action and Pharmacodynamic Effects
Reduces Mycobacterium tuberculosis infection level by inhibiting the 70S ribosome and fatty acid synthase critical for mycobacterial growth. It has bacteriostatic rather than bacteriocidal action.
External links