Ligand id: 7290

Name: rabeprazole

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 96.31
Molecular weight 359.13
XLogP 1.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to promote healing and symptomatic relief in patients with duodenal ulcers and erosive or ulcerative gastroesophageal reflux disease (GERD). This drug is also used to treat hypersecretion of gastric acid associated with other pathological conditions.
Mechanism Of Action and Pharmacodynamic Effects
Rabeprazole irreversibly inhibits the gastric potassium-transporting ATPase. This proton pump is responsible for secreting H+ ions into the stomach, creating acidic pH. View further gene and protein details for the transporter subunits on the H+/K+-ATPases page.
External links