testolactone

Ligand id: 7303

Name: testolactone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 43.37
Molecular weight 300.17
XLogP 3.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat advanced stage breast cancer.
Mechanism Of Action and Pharmacodynamic Effects
Testolactone inhibits the production of estrogen by inhibiting the aromatase enzyme (aka cytochrome P450 19A1 or CYP19A1) which is essential for the conversion of androstenedione to estrone. Drug treatment helps prevent the growth of breast cancers that are activated by estrogen.