Ligand id: 7316

Name: trimethadione

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 46.61
Molecular weight 143.06
XLogP -0.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Trimethadione is used to control absence seizures.
Mechanism Of Action and Pharmacodynamic Effects
This drug's molecular mechanism of action (MMOA) may involve inhibition of voltage-dependent T-type calcium channels. CACNA1E, CACNA1H and CACNA1I alpha subunits are detailed in this database, in the Voltage-gated calcium channels section. Blocking these channels is believed to prevent the hypersynchronisation of neuronal firing which underlies seizure generation. See the DrugBank link for further details.