Ligand id: 7330

Name: dexrazoxane

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 105.8
Molecular weight 268.12
XLogP -1.3
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to reduce the incidence and severity of cardiomyopathy associated with chemotherapy with anthracycline drugs. Dexrazoxane is also used to control tissue damage caused by accidental leakage of anthracycline at iv sites.
Mechanism Of Action and Pharmacodynamic Effects
As dexrazoxane is a derivative of the chelating agent EDTA, its ability to reduce/prevent cardiomyopathy is believed to involve chelation of iron which leads to reduced levels of iron-mediated free radical generation. These free radicals are thought to irreversibly damage DNA which causes damage to the heart muscle.
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