Ligand id: 7351

Name: vortioxetine

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View more information in the IUPHAR Pharmacology Education Project: vortioxetine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 40.57
Molecular weight 298.15
XLogP 4.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved for the treatment of major depressive disorder (MDD). Clinical formulations contain vortioxetine hydrobromide (PubChem CID 56843850).
Mechanism Of Action and Pharmacodynamic Effects
Vortioxetine is both a serotonin modulator and stimulator [1]. The Wikipedia page for the drug lists its potential pharmacological targets. The targets include serotonin 5-HT receptors, the serotonin transporter, SERT (SLC6A4) and norepinephrine transporter, NET (SLC6A2). Activity at β1-adrenoceptors may be associated with side effects of the drug [1].
External links