bazedoxifene

Ligand id: 7355

Name: bazedoxifene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 57.86
Molecular weight 470.26
XLogP 5.92
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Bazedoxifene is approved in combination with conjugated estrogens for the treatment of postmenopausal symptoms, including prevention of postmenopausal osteoporosis and osteopenia. These are the first approved hormone replacement therapy (HRT) products that contain a SERM and an estrogen, but do NOT require inclusion of a progestin. This is an advantage, as progestins in HRT therapies can cause dilaterious and unwanted side effects.
Mechanism Of Action and Pharmacodynamic Effects
Selective estrogen receptor modulators (SERMs) act on the estrogen receptor, but their agonist or antagonist action depends on the site of action/tissue type.