ibudilast

Ligand id: 7399

Name: ibudilast

Structure and Physico-chemical Properties

2D Structure
No information available.
Summary of Clinical Use
Ibudilast is an anti-inflammatory and neuroprotective drug. It prolongs time-to-first relapse and attenuates brain volume shrinkage in patients with relapsing-remitting (RR) and/or secondary progressive (SP) multiple sclerosis (MS). However, there is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Mechanism of action is complex, involving PDE inhibition, NO inhibition, and reduction in reactive oxygen species (neuroprotective action).