cilomilast

Ligand id: 7407

Name: cilomilast

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 79.55
Molecular weight 343.18
XLogP 2.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Cilomilast is being investigated for the treatment of conditions such as chronic obstructive pulmonary disease (COPD), bronchopulmonary dysplasia and asthma. ClinicalTrials.gov lists one completed trial for this compound (NCT00103922)
Mechanism Of Action and Pharmacodynamic Effects
Cilomilast is a selective phosphodiesterase-4 (PDE4) inhibitor IC50 120nM [2]. This action is believed to confer the compound's anti-inflammatory activity. In vitro studies have shown that cilomilast suppresses LPS-induced TNF-α formation in isolated human monocytes (pIC50 7.0) and produces a modest inhibition of fMLP-induced degranulation of human neutrophils (pIC50 7.1) [1].