Ligand id: 7407

Name: cilomilast

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 79.55
Molecular weight 343.18
XLogP 2.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Barnette MS, Christensen SB, Essayan DM, Grous M, Prabhakar U, Rush JA, Kagey-Sobotka A, Torphy TJ. (1998)
SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions.
J. Pharmacol. Exp. Ther., 284 (1): 420-6. [PMID:9435206]
2. Griswold DE, Webb EF, Badger AM, Gorycki PD, Levandoski PA, Barnette MA, Grous M, Christensen S, Torphy TJ. (1998)
SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivo.
J. Pharmacol. Exp. Ther., 287 (2): 705-11. [PMID:9808700]