dacomitinib

Ligand id: 7422

Name: dacomitinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 79.38
Molecular weight 469.17
XLogP 3.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Dacomitinib has been assessed in clinical trials for the treatment of non-small cell lung cancer ((NSCLC), and although some studies have failed to meet study goals, further trials are ongoing. Visit ClinicalTrials.gov to view currently registered drug trials involving this compound.
Mechanism Of Action and Pharmacodynamic Effects
Dacomitinib is an irreversible inhibitor of HERs (EGFR, and ERBBs).