Ligand id: 7426

Name: lenvatinib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 115.57
Molecular weight 426.11
XLogP 2.29
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
In 2015 lenvatinib was approved for use in treating patients with progressive, differentiated thyroid cancer. Lenvatinib has reached Phase III trials for hepatocellular cancers. Visit ClinicalTrials.gov to view currently registered drug trials assessing this compound's effectiveness in treating additional types of cancer.
Marketed formulations contain lenvatinib mesylate (PubChem CID 11237762).
In May 2016, the US FDA expanded approval to include treatment (in combination with everolimus) of advanced renal cell carcinoma following one prior anti-angiogenic therapy.
Mechanism Of Action and Pharmacodynamic Effects
Lenvatinib is an inhibitor of all three VEGFR tyrosine kinases [1]. Inhibits vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis and may therefore reduce the vascularisation which underpins and supports tumour development and growth.
External links