zopiclone   Click here for help

GtoPdb Ligand ID: 7430

Synonyms: compound 3 [PMID: 8863805] [1] | RP-27267 | Zimovane®
Approved drug
zopiclone is an approved drug
Compound class: Synthetic organic
Comment: Zopiclone is a racemic mixture of the R and S chemical stereoisomers (PubChem CID 941731 and eszopiclone respectively). Eszopiclone is an approved drug in its own right.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: zopiclone

zopiclone is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 91.76
Molecular weight 388.11
XLogP 0.29
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN1CCN(CC1)C(=O)OC1c2nccnc2C(=O)N1c1ccc(cn1)Cl
Isomeric SMILES CN1CCN(CC1)C(=O)OC1c2nccnc2C(=O)N1c1ccc(cn1)Cl
InChI InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3
InChI Key GBBSUAFBMRNDJC-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Zopiclone is used to treat insomnia. This drug is not approved by the US FDA and does not have pan-European (EMA) marketing authorisation. It appears that individual national approval agencies have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Zopiclone is a nonbenzodiazepine hypnotic sedative. Although chemically unrelated to the benzodizepines, this drug has an identical mechanistic action, binding to the benzodiazepine binding site on central GABAA ion channels and allosterically potentiating GABA-ergic neuro-inhibition.
External links Click here for help
For extended ADME data see the following:

Electronic Medicines Compendium (eMC)