zopiclone

Ligand id: 7430

Name: zopiclone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 91.76
Molecular weight 388.11
XLogP 0.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Zopiclone is used to treat insomnia. This drug is not approved by the US FDA and does not have pan-European (EMA) marketing authorisation. It appears that individual national approval agencies have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Zopiclone is a nonbenzodiazepine hypnotic sedative. Although chemically unrelated to the benzodizepines, this drug has an identical mechanistic action, binding to the benzodiazepine binding site on central GABAA ion channels and allosterically potentiating GABA-ergic neuro-inhibition.
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