Ligand id: 7435

Name: levomilnacipran

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 46.33
Molecular weight 246.17
XLogP 3.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat major depressive disorder [1]. Clinical formulations contain levomilnacipran hydrochloride (PubChem CID 6917778).
Mechanism Of Action and Pharmacodynamic Effects
Levomilnacipran inhibits reuptake of serotonin and noradrenaline by their respective transporters, SERT (SLC6A4) and NET (SLC6A2). By inhibiting the re-uptake of serotonin and norepinephrine in the CNS, this drug rebalances the levels of these neurotransmitters and increases their activity. This improves symptoms of depression and anxiety.
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