Ligand id: 7435

Name: levomilnacipran

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View more information in the IUPHAR Pharmacology Education Project: levomilnacipran

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 46.33
Molecular weight 246.17
XLogP 3.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Citrome L. (2013)
Levomilnacipran for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant--what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?.
Int. J. Clin. Pract., 67 (11): 1089-104. [PMID:24016209]
2. Deprez D, Chassard D, Baille P, Mignot A, Ung HL, Puozzo C. (1998)
Which bioequivalence study for a racemic drug? Application to milnacipran.
Eur J Drug Metab Pharmacokinet, 23 (2): 166-71. [PMID:9725476]
3. Vickers T, Dyck B, Tamiya J, Zhang M, Jovic F, Grey J, Fleck BA, Aparicio A, Johns M, Jin L et al.. (2008)
Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors.
Bioorg. Med. Chem. Lett., 18 (11): 3230-5. [PMID:18468895]