milnacipran

Ligand id: 7436

Name: milnacipran

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 46.33
Molecular weight 246.17
XLogP 3.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
In addition to treating major depressive disorder, milnacipran can be used to treat the chronic pain disorder fibromyalgia [1-2].
Mechanism Of Action and Pharmacodynamic Effects
Milnacipran inhibits reuptake of serotonin and noradrenaline by their respective transporters, SERT (SLC6A4) and NET (SLC6A2). By inhibiting the re-uptake of serotonin and norepinephrine in the CNS, this drug rebalances the levels of these neurotransmitters and increases their activity. It is likely that the inihibition of noradrenaline reuptake is responsible for improvements in chronic pain management.
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