milnacipran

Ligand id: 7436

Name: milnacipran

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 46.33
Molecular weight 246.17
XLogP 3.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Arnold LM, Gendreau RM, Palmer RH, Gendreau JF, Wang Y. (2010)
Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: results of a randomized, double-blind, placebo-controlled trial.
Arthritis Rheum.62 (9): 2745-56. [PMID:20496365]
2. Moret C, Briley M. (2006)
Antidepressants in the treatment of fibromyalgia.
Neuropsychiatr Dis Treat2 (4): 537-48. [PMID:19412502]
3. Van Orden LJ, Van Dyke PM, Saito DR, Church TJ, Chang R, Smith JA, Martin WJ, Jaw-Tsai S, Stangeland EL. (2013)
A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: synthesis and structure-activity relationships.
Bioorg. Med. Chem. Lett.23 (5): 1456-61. [PMID:23347683]