velaglucerase alfa

Ligand id: 7464

Name: velaglucerase alfa

No information available.
Summary of Clinical Use
Velaglucerase alfa is approved to be used as an enzyme replacement therapy (ERT) for Gaucher's disease patients, whose own β-glucocerebrosidase is non-functional.
Mechanism Of Action and Pharmacodynamic Effects
Velaglucerase alfa is a glucocerebroside hydrolytic enzyme. The enzyme β-glucocerebrosidase (GBA, P04062), is a lysosomal enzyme that hydrolyses glucocerebroside as a step in glycolipid metabolism. β-glucocerebrosidase activity is impaired in Gaucher's disease and this results in accumulation of glucocerebroside. Velaglucerase alfa restores the deficient enzyme activity.
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