velaglucerase alfa   Click here for help

GtoPdb Ligand ID: 7464

Synonyms: EC 3.2.1.45 | VPRIV®
Approved drug
velaglucerase alfa is an approved drug (FDA and EMA (2010))
Compound class: Peptide or derivative
Comment: Velaglucerase alfa is a recombinant form of human β-glucocerebrosidase (GBA, P04062).
Its INN record describes it as human glucosylceramidase (EC 3.2.1.45 or beta-glucocerebrosidase), glycoform α.
Peptide Sequence Click here for help
ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKG
FGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPL
IHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGL
LSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPA
KATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDS
PIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFL
ETISPGYSIHTYLWRRQ
Post-translational Modification
Disulfide bridges locations: 4-16, 18-23
Glycosylation sites: Asn19, Asn59, Asn146, Asn270, Asn462