clevidipine

Ligand id: 7468

Name: clevidipine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 90.93
Molecular weight 455.09
XLogP 4.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Clevidipine is approved to treat hypertension in patients who are unable to take oral mediactions, for example during the perioperative period.
Mechanism Of Action and Pharmacodynamic Effects
Clevidipine is a L-type calcium channel blocker, selective for channels in the vasculature, rather than in the heart. Clevidipine reduces mean arterial blood pressure by decreasing systemic vascular resistance with little effect on myocardial contractility or cardiac conduction.
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