lacosamide

Ligand id: 7472

Name: lacosamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 67.43
Molecular weight 250.13
XLogP 1.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Lacosamide is used to treat partial-onset seizures in combination with other antiepileptic medicines and may be useful for treating diabetic neuropathic pain.
Mechanism Of Action and Pharmacodynamic Effects
Lacosamide has been shown experimantally, to be effective in blocking inactivated voltage-gated Nav1.3-, Nav1.7-, and Nav1.8-type channels which are thought to play important roles in pain mechanisms [3].
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