palonosetron

Ligand id: 7486

Name: palonosetron

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View more information in the IUPHAR Pharmacology Education Project: palonosetron

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 23.55
Molecular weight 296.19
XLogP 3.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to prevent nausea and vomiting caused by highly emetogenic cancer chemotherapy.
Mechanism Of Action and Pharmacodynamic Effects
Palonosetron is an antagonist of the serotonin 5-HT3 receptor. Many chemotherapies cause the release of serotonin from the enterochromaffin cells of the small intestine. This neurotransmitter is then able to activate 5-HT3 receptors in the gut and on vagal afferents which activates the vomiting reflex. By inhibiting the activity of endogenous serotonin at these receptors, the drug reduces chemotherapy related nausea and vomiting [1].
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