palonosetron

Ligand id: 7486

Name: palonosetron

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View more information in the IUPHAR Pharmacology Education Project: palonosetron

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 23.55
Molecular weight 296.19
XLogP 3.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. De Leon A. (2006)
Palonosetron (Aloxi): a second-generation 5-HT₃ receptor antagonist for chemotherapy-induced nausea and vomiting.
Proc (Bayl Univ Med Cent)19 (4): 413-6. [PMID:17106506]
2. Moura Barbosa AJ, De Rienzo F, Ramos MJ, Menziani MC. (2010)
Computational analysis of ligand recognition sites of homo- and heteropentameric 5-HT3 receptors.
Eur J Med Chem45 (11): 4746-60. [PMID:20724042]