dosulepin

Ligand id: 7549

Name: dosulepin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: dosulepin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 28.54
Molecular weight 295.14
XLogP 5.85
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Dosulepin is primarily used for the treatment of major depressive disorder [1], but may also be used to treat neuropathic pain and psychogenic facial pain. However, there is no information regarding marketing approval for this drug on the US FDA or European Medicines Agency (EMA) websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Dosulepin acts as a serotonin and norepinephrine reuptake inhibitor. This drug also has anticholinergic, antihistaminic and α1 adrenoceptor antagonist activity [5].