Ligand id: 7549

Name: dosulepin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 28.54
Molecular weight 295.14
XLogP 5.85
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Lancaster SG, Gonzalez JP. (1989)
Dothiepin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
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Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics.
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Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.
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4. Tatsumi M, Groshan K, Blakely RD, Richelson E. (1997)
Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
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5. (2011)
SECTION II: NEUROPHARMACOLOGY.  In  Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition
Edited by Brunton L, Chabner B, Knollman B (McGraw-Hill Professional) 1808. [ISBN:9780071624428]