estazolam

Ligand id: 7550

Name: estazolam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 43.07
Molecular weight 294.07
XLogP 4.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat insomnia [1-2].
Mechanism Of Action and Pharmacodynamic Effects
Estazolam is a GABAA receptor positive allosteric modulator, binding to the benzodiazepine allosteric site. This action has anxiolytic, muscle relaxant, anticonvulsant and sleep-promoting effects.
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