estazolam   Click here for help

GtoPdb Ligand ID: 7550

Synonyms: D 40TA | Eurodin® | ProSom®
Approved drug
estazolam is an approved drug (FDA (1990))
Compound class: Synthetic organic
Comment: Estazolam is an intermediate-acting oral benzodiazepine derivative with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant actions.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 42.55
Molecular weight 294.07
XLogP 5.65
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Clc1ccc2c(c1)C(=NCc1n2cnn1)c1ccccc1
Isomeric SMILES Clc1ccc2c(c1)C(=NCc1n2cnn1)c1ccccc1
InChI InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2
InChI Key CDCHDCWJMGXXRH-UHFFFAOYSA-N
References
1. Dominguez RA, Goldstein BJ, Jacobson AF, Steinbook RM. (1986)
Comparative efficacy of estazolam, flurazepam, and placebo in outpatients with insomnia.
J Clin Psychiatry, 47 (7): 362-5. [PMID:2873132]
2. Post GL, Patrick RO, Crowder JE, Houston J, Ferguson JM, Bielski RJ, Bailey L, Pearlman HG, Shu VS, Pierce MW. (1991)
Estazolam treatment of insomnia in generalized anxiety disorder: a placebo-controlled study.
J Clin Psychopharmacol, 11 (4): 249-53. [PMID:1918423]