gabapentin enacarbil

Ligand id: 7560

Name: gabapentin enacarbil

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View more information in the IUPHAR Pharmacology Education Project: gabapentin enacarbil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 101.93
Molecular weight 329.18
XLogP 3.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Indicated for the treatment of restless leg syndrome. May also be used to treat post-herpetic neuralgia.
Mechanism Of Action and Pharmacodynamic Effects
This is the MMOA for the active drug, gabapentin: Gabapentin is a voltage-gated calcium channel modulator which acts via a cascade involving GABA receptors, to reduce the release of monoamine neurotransmitters, potentially in the CA1 area of the hippocampus.