butorphanol

Ligand id: 7591

Name: butorphanol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 43.7
Molecular weight 327.22
XLogP 3.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the management of moderate to severe pain. It might also be used as component of anesthesia for surgery, or as pain relief during early labour. This drug is currently available only as generic formulations.
Mechanism Of Action and Pharmacodynamic Effects
Butorphanol is a morphinan-type synthetic opioid analgesic. It acts as a partial agonist and antagonist at the κ and μ opioid receptors [2]. Activation of these receptors on central nervous system neurons inhibits intracellular adenylate cyclase. Downstream this leads to reduced calcium influx via membrane calcium channels, and increased potassium permeability by opening membrane potassium channels. This ultimately leads to hyperpolarization of the cell membrane potential and suppression of action potential transmission of ascending pain pathways.
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