pralidoxime

Ligand id: 7597

Name: pralidoxime

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 36.47
Molecular weight 137.07
XLogP 1.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Pralidoxime is used to treat organophosphate poisoning, including poisoning with acetylcholinesterase inhibitor type nerve agents such as sarin, usually in conjunction with atropine and diazepam. Occasionally used to treat overdoses of clinically administered acetycholinesterase inhibitors such as neostigmine and pyridostigmine, or anticholinergic overdose.
Mechanism Of Action and Pharmacodynamic Effects
The drug binds to the anionic site of acetylcholinesterase when the enzyme's esteric site is occupied by organophosphate. This results in a conformational change that releases the pralidoxime-organophosphate complex, and restores acetylcholinesterase activity.
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