Ligand id: 7606

Name: fludroxycortide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 93.06
Molecular weight 436.23
XLogP 0.65
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Fludroxicortide is a topical corticosteroid drug. It is used to relieve inflammatory and pruritic symptoms of corticosteroid-responsive skin conditions.
Mechanism Of Action and Pharmacodynamic Effects
Fludroxicortide is a glucocorticoid receptor (GR) agonist. The GR-drug complex translocates to the nucleus where it transactivates the expression of genes containing glucocorticoid response elements (GREs). Target genes include those for anti-inflammatory proteins and the net effect is a reduction of prostaglandin and leukotriene biosynthesis.
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