uramustine

Ligand id: 7621

Name: uramustine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 61.44
Molecular weight 251.02
XLogP 0.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Antineoplastic action is used to treat lymphatic malignancies eg non-Hodgkin's lymphoma. However, there is no information regarding approval of this drug on either the US FDA or EMA websites. Individual national approval agencies may have granted marketing authorisation for this drug.
Mechanism Of Action and Pharmacodynamic Effects
Uramustine binds preferentially to the guanine and cytosine nucleotides in DNA, leading to DNA cross-linking, and subsequently inhibits DNA synthesis and function. This results in cell death. At high doses RNA and protein synthesis are also inhibited.