Ligand id: 7654

Name: dienogest

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 61.09
Molecular weight 311.19
XLogP 1.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Fixed-mixture combination drugs containing dienogest and estradiol valerate are used as combined oral contraceptives (COCs) to prevent pregnancy, or may also be used to reduce heavy menstrual bleeding. The COCs include brands such as Natazia®, Qlaira® and Delestrogen®. Such drugs are covered by PubChem CID 9874560.
Mechanism Of Action and Pharmacodynamic Effects
COCs reduce the risk of pregnancy by primarily supressing ovulation, but also effect changes which render the cervix and endometrium hostile to sperm.