cariprazine

Ligand id: 7671

Name: cariprazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 38.82
Molecular weight 426.2
XLogP 3.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
In September 2015, the US FDA approved cariprazine for the treatment of schizophrenia and bipolar disorder. Click here to view ClinicalTrials.gov's current list of cariprazine drug trials.
Mechanism Of Action and Pharmacodynamic Effects
Cariprazine acts as a dopamine D2 and D3 receptor partial agonist, with preference for the D3 receptor subtype [1,3].