cariprazine

Ligand id: 7671

Name: cariprazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 38.82
Molecular weight 426.2
XLogP 3.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Agai-Csongor E, Domány G, Nógrádi K, Galambos J, Vágó I, Keserű GM, Greiner I, Laszlovszky I, Gere A, Schmidt E et al.. (2012)
Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.
Bioorg. Med. Chem. Lett.22 (10): 3437-40. [PMID:22537450]
2. Gründer G. (2010)
Cariprazine, an orally active D2/D3 receptor antagonist, for the potential treatment of schizophrenia, bipolar mania and depression.
Curr Opin Investig Drugs11 (7): 823-32. [PMID:20571978]
3. Kiss B, Horváth A, Némethy Z, Schmidt E, Laszlovszky I, Bugovics G, Fazekas K, Hornok K, Orosz S, Gyertyán I et al.. (2010)
Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile.
J. Pharmacol. Exp. Ther.333 (1): 328-40. [PMID:20093397]