AZD4877

Ligand id: 7708

Name: AZD4877

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 107.77
Molecular weight 503.24
XLogP 6.82
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
AZD4877 causes mitotic arrest and leads to the formation of the monopolar spindle phenotype characteristic of KSP inhibition. This action induces cell death [1].