Ligand id: 7767

Name: cilnidipine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 117
Molecular weight 492.19
XLogP 8.03
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Cilnidipine is to treat hypertension. According to the website this compound has marketing approval in Japan (AtelecTN, CinalongTN), China (JiuyueTN), South Korea (CinalongTN) and India (CilacarTN).
Mechanism Of Action and Pharmacodynamic Effects
Cilnidipine blocks activity of N-type and L-type calcium channels. This causes dilateion of both arterioles and venules to bring about a reducetion in blood pressure.