Ligand id: 7784

Name: CCG-50014

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 65.92
Molecular weight 316.07
XLogP 4.62
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
CCG-50014 forms a covalent bond with two cysteine residues located in an allosteric regulatory site of RGS4 [1]. This action increases GTP hydrolysis and reduces activation of the G-protein Gα subunit, thereby negatively regulating G-protein-coupled receptor signalling.