Ligand id: 7880

Name: CEP-32496

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 120.63
Molecular weight 517.16
XLogP 5.43
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
CEP-32496 is being assessed in Phase II clinical trial NCT01877811 for melanoma and metastatic colorectal cancer.
Mechanism Of Action and Pharmacodynamic Effects
The constitutively activating RAF mutation BRAFV600E is frequently found in human tumors and causes over-activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. CEP-32496 inhibits this abberant activation and may result in a decrease in the proliferation of tumor cells expressing the mutated B-raf gene.