xipamide

Ligand id: 7900

Name: xipamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 117.87
Molecular weight 354.04
XLogP 2.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Xipamide is used for the treatment of oedema and hypertension.
This drug is not approved by the US FDA or EMA. It has been used in the UK since 2002, and is available in other countries under various trade names. Click here to link to Drugs.com's list of internationally marketed xipamide drugs.
Mechanism Of Action and Pharmacodynamic Effects
Xipamide acts on the kidneys in a similar manner to the thiazide diuretics, acting to reduce sodium reabsorption in the distal convoluted tubule. These drugs block the active reabsorption of chloride in the ascending loop of Henle by inhibiting the thiazide-sensitive sodium-chloride symporter, NCC (SLC12A3). This results in excretion of sodium, chloride and water, thus reducing fluid retention and oedema. At high concentrations xipamide can also inhibit carbonic anhydrases [1].
External links