binimetinib

Ligand id: 7921

Name: binimetinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 88.41
Molecular weight 440.03
XLogP 2.88
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Two Phase III clinical trials for BRAF and NRAS mutation +ve metastatic melanoma are underway, and another Phase III for low-grade serous ovarian, fallopian tube or peritoneal cancer is recruiting participants (Nov 2014). Click here to link to ClinicalTrials.gov's full list of Phase III MEK162 trials. Phase II trial results for melanoma are available in [1].