Ligand id: 7968

Name: BMS-908662

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 107.55
Molecular weight 462.11
XLogP 5.38
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A Phase I/II clinical trial has been completed. This trial (NCT01086267) assessed BMS908662 alone or in combination with the approved anti-EGFR monoclonal antibody cetuximab, in patients with K-RAS or B-RAF mutation positive advanced or metastatic colorectal cancer.