Ligand id: 8099

Name: AGK2

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 78.92
Molecular weight 433.04
XLogP 5.57
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
AGK2 inhibits deacetylation of α-tubulin by SIRT2 [3]. It also protects neuronal cells against α-Syn–mediated toxicity in a Drosophila model of Parkinson's disease [3].