vactosertib

Ligand id: 8107

Name: vactosertib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 83.79
Molecular weight 399.16
XLogP 4.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
EW-7197 (research coded TEW-7197) is being evaluated in Phase 1 clinical trials: NCT02160106 (a first in human dose escalation study in patients with solid tumours) and NCT03143985 (in combination with pomalidomide in patients with relapsed or relapsed/refractory multiple myeloma).